… Mutations in GRN are one of the major causes of FTLD and found in 11.2% of patients,
therefore progranulin is an important emerging target to develop better treatments (Abella et al., …

… of ubiquitin-positive inclusion bodies. Since then, more than 190 GRN mutations have been
… The tau-negative, ubiquitin-positive inclusions that were seen in GRN mutation brains were …

… Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar
degeneration… Neuropathologic features of frontotemporal lobar degeneration with …

… as a gene linked to frontotemporal lobar degeneration (FTLD). The first mutations identified
were null mutations giving rise to … of ubiquitin-positive frontotemporal lobar degeneration …

… Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to …
CHMP2B C-truncating mutations in frontotemporal lobar degeneration are associated with an …

… Genetic deficiency from loss-of-function mutations and single-nucleotide polymorphisms
may cause a reduction in progranulin levels. Progranulin deficiency has been implicated in …

… Together, our results demonstrate a strong association between progranulin deficiency and
… Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to …

… Autosomal dominant mutations of the progranulin (GRN) gene leading to protein … Null
mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome …

… GRN mutations result in FTLD-TDP type A, characterized by short dystrophic neurites,
ubiquitin-positive- neuronal cytoplasmic inclusions concentrated in neocortical layer 2 and often …

… cause of frontotemporal dementia. Most pathogenic GRN mutations result in progranulin
haploinsufficiency, which is thought to cause frontotemporal dementia in GRN mutation …